1. What is Sotane? Sultan is a multi-targeted tumor therapeutic drug produced by Pfizer. Its indications include (1) Gastrointestinal mesenchymal stromal tumors (GIST) that have failed or are intolerant to imatinib mesylate treatment; (2) inoperable advanced renal cell carcinoma (RCC); (3) inoperable renal cell carcinoma (RCC); and (4) inoperable renal cell carcinoma (RCC). It is indicated for (1) gastrointestinal mesenchymal stromal tumor (GIST) that has failed or is intolerant to imatinib mesylate therapy, and (2) inoperable advanced renal cell carcinoma (RCC). 2. What is the Sotan Patient Assistance Program? The Sotan Patient Assistance Program is a charitable program. It provides assistance to needy patients with tumors that are suitable for treatment with Sultan. Of course, there is a rigorous evaluation of medical and financial conditions to determine who is eligible for assistance. 3. What does the office of the Sotan Patient Assistance Program do? In order to ensure the smooth operation of the program and the timely delivery of the drug to patients in need, the China Cancer Fund has set up a special office to be fully responsible for the work of the Sotane Patient Assistance Program. The program office is responsible for the management of the entire Sotane Patient Assistance Program. The work includes the development of workflow, work standards, and the designation of program doctors and drug distribution sites, economic evaluation of patients, etc., to ensure the timely supply of Sotentan to patients eligible for the program. 4. How do I apply for the Sotan Patient Assistance Program? First of all, please go to the designated doctor of the program, and the designated doctor will confirm that you meet the medical criteria of the Sotan Assistance Program, and fill out the medical condition confirmation form and issue a prescription for Sotan. The designated doctor will also provide you with a “Patient Information Kit” and a “Patient Financial Questionnaire”. Then, please read the “patient folder” carefully and fill in the program application materials as required, and then the China Cancer Fund’s “Sotane Patient Assistance Program Office” will evaluate your financial situation, determine the qualified patients to be assisted and issue a “Notice of Entry into the Program”. Eligible patients will go to the designated distribution point to receive the donated drugs with the notice. 5. How do I get my free medication after I submit my application? First of all, the program office will verify and approve the application materials sent by you upon receipt. Generally, if the materials are complete and valid, we will give you a reply within 10 working days. If you are approved to enter the Sotane Assistance Program, we will send you a “Sotane Patient Assistance Program Patient ID Card” and a copy of your Sotane prescription stamped by the program office, along with other information, and notify your designated doctor and dispenser. Afterwards, please contact the dispenser in time to receive your medication. You will then be able to collect your free medication from the designated dispensing location with your Patient ID Card, a copy of your Sultan prescription stamped by the program office, and your ID card. 6. How much Sultan can I receive at one time? Patients who receive assistance from the program can only receive one treatment cycle of Sultan at a time (4 vials of the regular dose), and then the designated doctor will need to give you a medical evaluation to determine if you need to continue your Sultan treatment. 7. Where are the Sotane medications picked up (distributed)? There are currently donation distribution centers in 32 cities across the country, and the program office will notify you of the address when you are approved to enter the program. 8. Can I apply for the program if I am not in one of the cities? Yes, you can. However, you must go to one of the 39 cities where the program operates (a detailed list is available on the website) to be diagnosed by one of the designated doctors at one of the designated hospitals. Currently, the designated doctors are only available in these 39 cities, so if you are not in one of these cities, it may take a longer time for your application to be reviewed. Please understand! 9. I am a patient who has already been approved to enter the Sotan Patient Assistance Program, can I be referred to another designated doctor in the approved region? In principle, no. This is for the benefit of your treatment, to ensure the long-term efficacy of your follow-up and the safety of your medication, as well as to ensure that you receive timely and continuous assistance with Sotentan. Please do not make any referrals. If there are special circumstances that require a referral, please provide the program office with a written request and explanation of the reasons for the referral, which will be valid only after the program office has approved the referral and gone through the relevant procedures. 10. Regarding my medical evaluation and return visit, are there any requirements on what kind of tests must be done? No. The program does not require any specific tests to be done, but rather it is up to the designated doctor to decide on the tests according to your situation.