Human papillomavirus (HPV) can be contracted through a variety of routes. HPV infection can be transmitted through blood, sexual contact, indirect contact and mother-to-child transmission, with the main route of infection being sexual intercourse. The impact of sexual behavior on HPV infection is certain, especially the number of male sexual partners, as well as the male sexual partners themselves have multiple sexual partners can increase the risk of HPV infection. Not using condoms or taking other tools for contraception also increases the risk of causing HPV infection, and also immunosuppressed states, such as kidney transplant or Hodgkin’s disease patients, predispose to HPV infection. Most HPV infections are transient, and the natural clearance time for cervical HPV infection is 7 to 12 months. Most infections are subclinical and insidious, and their lesions are self-limiting and reversible, with only some developing into persistent infections. The main route of HPV infection is through sexual contact, but not exclusively, but also through other routes.