The main component of soot is carbon monoxide, and it is important to get out of the poisoned environment and correct hypoxia immediately after poisoning, as well as to prevent and treat cerebral edema and other complications. 1. Get out of the poisoned environment: open windows and ventilate, and make the patient get out of the poisoned environment quickly and move to a place with fresh air. Loosen the collar and belt of the patient, pay attention to warmth, and ensure the smooth flow of the respiratory tract. If there is respiratory arrest, give cardiopulmonary resuscitation treatment in time; 2. Correct oxygen deficiency: carbon monoxide can form carboxyhemoglobin with hemoglobin in the body, which interferes with the transport and utilization of oxygen in the body. Oxygen needs to be provided quickly to meet the body’s need for oxygen. For patients with severe poisoning, hyperbaric oxygen therapy is preferred, which can rapidly improve and correct tissue hypoxia, accelerate dissociation and clearance of carbon monoxide, shorten the course of the disease and reduce the rate of death. Generally, hyperbaric oxygen therapy requires about 5-7 times for mild poisoning, 10-20 times for moderate poisoning, and usually 20-30 times for severe poisoning; 3. Prevention and control of cerebral edema: patients can show cerebral edema after 2 hours of acute poisoning, which usually reaches its peak in about 48 hours, and patients need to be given diuretics for dehydration and lowering cranial pressure, as well as correcting water and electrolyte disorders that appear in the treatment. For patients with frequent convulsions, diazepam and chloral hydrate can be given for sedation as prescribed by the doctor. Patients with high fever should pay attention to physical cooling of the head, and hibernation therapy should be given if necessary; 4. Prevention and control of other complications: under the guidance of a professional physician, appropriate supplementation of B vitamins, coenzyme A, adenosine triphosphate, cytophosphatidylcholine, brain activator, and other substances should be given to promote the recovery of brain cell function and prevent the occurrence of delayed encephalopathy. In addition, during the coma period, it is important to ensure a clear airway, strengthen symptomatic support treatment, and prevent and treat complications such as pulmonary infections and decubitus ulcers.