Helicobacter pylori can not kill the reasons: 1, infected with drug-resistant bacteria: If susceptible people and have drug-resistant bacteria infected people eat together, the first infection that can be drug-resistant bacteria; 2, the initial treatment is not formal: not according to the course of medication; triple therapy has been eliminated, still using triple therapy, if it can not kill it can become drug-resistant bacteria, causing difficulties for future sterilization; 3, sterilization when the choice of easily resistant antibiotics, such as metronidazole file, clarithromycin, levofloxacin, etc. Such as metronidazole file, clarithromycin, levofloxacin, etc. 4, sterilization did not pay attention to remove the impact of factors: such as eating too acidic and sweet food, smoking, etc. 5, according to the bacteria to drug resistance rate selection of antibiotics: H. pylori can not kill how to do? 1, epidemiological and drug resistance rate survey : epidemiological surveys show that the overall rate of Hp infection in China is still very high, the infection rate among adults reached 40% to 60% “. Among the six antimicrobial drugs recommended for eradication therapy, the resistance rate of metronidazole reaches 60% to 70%, clarithromycin reaches 20% to 38%” and levofloxacin reaches 30% to 38%, and the resistance significantly affects the eradication rate; the resistance rate of amoxicillin, vindazone and tetracycline is still very low (1% to 5%). Antibiotics with low resistance rates should be selected. 2. If after treatment with 2 of the regular quadruple regimens, both for 10 or 14 days, failure is highly likely when re-treated after failure. In this case, the risk-benefit ratio of eradication therapy needs to be evaluated. Gastric lymphoma, peptic ulcer with history of complications, gastritis with risk of gastric cancer (severe total gastritis, gastric body-dominant gastritis or severe atrophic gastritis, etc.), and those with family history of gastric cancer have greater benefit from Hp eradication. 3. The selection of the program needs to be carefully designed by experienced doctors based on comprehensive evaluation of the used drugs and analysis of the possible causes of failure. If available, drug sensitivity tests can be performed, but the effect may be limited. Emphasis on individualized treatment: The selection of regimen, course and drugs needs to take into account the history of previous antimicrobial drug applications (clarithromycin, levofloxacin, metronidazole are prone to resistance), smoking (reduces efficacy), history of drug (amoxicillin, etc.) allergy and potential adverse reactions, indications for eradication (peptic ulcer eradication rate is higher than non-ulcer dyspepsia); concomitant diseases (affects drug metabolism, excretion, increases adverse reactions) and age (increased incidence of adverse drug reactions and reduced benefit rate in patients of advanced age), etc. 1. Remedial therapy: 2 to 3 months interval is recommended. 2.PPI plays an important role in eradication regimen: choosing PPI with stable action, high efficacy and less affected by genetic polymorphism, such as esomeprazole and rabeprazole, can improve the eradication rate. 3, sequential therapy: that is, proton pump inhibitors, bismuth preparations, amoxicillin (penicillin is not allergic) based on sequential use of tetracycline and furazolidone, can obtain better results. 4, Chinese medicine: the results of a study suggest that a certain Chinese medicine has the effect of improving the eradication rate of Hp, but the exact efficacy and how to combine the eradication program, but more studies have yet to be verified.