The health of the baby is the greatest wish of every mother and father. How to get a healthy baby after the delivery of a mother with major triplets is a topic of great concern to everyone. To interrupt transmission a combination of hepatitis B vaccine and hepatitis B immunoglobulin must be taken in newborns for prevention. Hepatitis B vaccine: 20 μg is needed each time, and the routine injections are one within 24 hours, one at 1 month and one at 6 months; preferably, one additional injection is given at the 2nd month. Why is this necessary? The mother’s virus is contaminating the newborn during delivery, and the incubation period for establishing infection takes about 2 months. Infants need repeated injections of the vaccine for their bodies to gradually produce sufficient antibodies, so the earlier the injection is started, the better; an additional injection at 2 months has a booster effect. In China, the dose of hepatitis B vaccine is insufficient, and more than 20% of newborns of mothers with “major triple-positive” disease fail in prevention, so the assistance of hepatitis B immunoglobulin is also needed. Hepatitis B immunoglobulin: It takes 2 to 3 months for a small amount of antibodies to be produced in infants who have been vaccinated against hepatitis B. In order to obtain early protection, hepatitis B immunoglobulin must also be injected within 24 hours of birth. Antibodies can appear in the serum after the injection is absorbed, and there is protection. The dose of hepatitis B immunoglobulin needs to be 200 units and must be injected on a different side of the hip from the vaccine so that the vaccine (antigen) will not be neutralized locally with the globulin (antibody). The combination of hepatitis B vaccine and hepatitis B immune globulin provides more than 90% protection for newborns of mothers with “major triplets”. It is important to note that some mothers think that a cesarean section will reduce the rate of mother-to-child transmission, but some studies have shown that a cesarean section has the same chance of transmission as a natural birth.