Patient: 10 years ago he was found to have triple III, his liver function has been normal and untreated. Now I am 39 weeks pregnant, and the viral DNA is 1.4 times 10 to the eighth power. I would like to ask the doctor if I have to have a cesarean section for the sake of the child’s health, and if I can’t breastfeed after the birth? And I can’t breastfeed after delivery? And what is the possibility of intrauterine infection in the baby if my viral replication rate is so high? I sincerely look forward to your reply! Hepatitis Wu Chao: Firstly, go to a qualified tertiary hospital or above, and immediately after the birth of the child (within 24 hours, the earlier, the better) inject high-valent Hepatitis B Immunoglobulin (HBIG), and according to the national immunization plan, and at the same time inject Hepatitis B vaccine (and then in the following January, and then again in June, two times), usually able to interrupt the transmission of mother-to-child transmission (the effective rate can be more than 95%). Secondly, there is no evidence-based medical evidence that injecting high-value hepatitis B immunoglobulin in the second trimester of pregnancy can stop vertical transmission! Therefore, there is no need to inject high-valent hepatitis B immunoglobulin in the second trimester of pregnancy; it is not beneficial and even more ineffective. Thirdly, there are some clinical studies that prove that the use of nucleoside antiviral drugs (Tebivudine) in late pregnancy (after 24 weeks) can increase the blocking effect and reduce the possibility of vertical transmission even more; Fourthly, there is no sufficient evidence to prove that cesarean section reduces the chances of transmission of hepatitis B from mother to child. Fourth, there is insufficient evidence that cesarean section reduces the chance of mother-to-child transmission of hepatitis B. There is no standardized definition of intrauterine transmission, and the most important thing is the immunization of the child at birth. Fifth, many studies have shown that even in the case of high viral load (HBVDNA), breastfeeding does not increase the rate of hepatitis B infection in infants on a strict immunoblocking regimen, i.e., infants born with high-valent hepatitis B immune globulin and hepatitis B vaccine, and thus, it is perfectly safe to breastfeed a mother who is tertiary, as well as a woman who is DNA-positive. For reference only, it is recommended to consult a specialist or specialist hospital in your local hospital.