Hepatitis B infection is characterized by the presence of a number of viral markers in the blood serum, which are called “two halves”. “Major triple positive”, “Minor triple positive” and “Minor bi-positive” are the vernacular words used by the people to describe the “two halves”, which have become popular nationwide. It has become popular throughout the country. How do the terms “major triple positive”, “minor triple positive” and “minor double positive” change and what are their different clinical significance? Liu Guangwei, Department of Spleen, Gastroenterology, Hepatobiliary Diseases, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, What are the signs of “Hepatitis B two half”? The five signs together are two and a half, two antigens are produced by the hepatitis B virus; three antibodies are produced by the body’s lymphocyte immune response to the virus.1. Surface antigen (HBsAg) is positive: signifies that the hepatitis B virus is infected, and there is hepatitis B virus (HBV) in the body, but it does not indicate whether the virus is actively replicating, and whether the condition is mild or severe, and whether the condition is acute or chronic.2. Surface antibody (anti-HBs) is positive: It means that the hepatitis B virus has produced protective immunity against the virus after infection; or the immune response has occurred after injection of hepatitis B vaccine, which is protective antibody and will not be infected with hepatitis B virus again.3. Positive E antigen (HBeAg): It reflects that the hepatitis B virus is actively replicating and the blood is highly contagious, but it does not indicate whether the disease is mild or serious.4. Positive E antibody (anti-HBe): There are two very different situations of the presence of E antibody: there are two types of E antibody, namely There are two different situations: ① in the serum aminotransferase continues to be normal, it means that the replication of hepatitis B virus is very low and low, and HBV DNA can not be detected in serum, and it is in the recovery period of the infection; ② in the serum aminotransferase is elevated, or sometimes high and sometimes low, and HBV DNA can be detected in the chronic hepatitis B of “small triple positive”, because of viral mutation, so the “small triple positive” chronic hepatitis B can be detected, because the “small triple positive” chronic hepatitis B can be detected in the blood. Viral mutation, so “small triple positive” chronic hepatitis patients are prone to relapse after treatment. 5, core antibody (anti-HBc) positive: it should be viewed in conjunction with other markers to illustrate the problem, there are two different situations: ① and HBsAg positive at the same time indicates that the hepatitis B virus infection; ② and anti-HBs at the same time indicates that the positive infection has acquired immunity against hepatitis B virus; ② and anti-HBs positive at the same time indicates that the infection has acquired immunity against hepatitis B virus. (b) Positive with anti-HBs indicates that after infection, immunity against the hepatitis B virus has been acquired. According to the above order, 1, 3 and 5 positive items are “major triple positive”; the 3rd E antigen of “major triple positive” is converted to the 4th E antibody, i.e. 1, 4 and 5 positive, which is called “minor triple positive” in local language; if the 3rd E antigen is converted to the 4th E antibody, i.e. 1, 4 and 5 positive, which is called “minor triple positive” in local language. “If the 3rd E antigen disappears and the 4th E antibody fails to come out, i.e., 1 and 5 positive, it is called “Xiao Er Yang”. Regardless of “major tri-positive”, “minor tri-positive” or “minor b-positive”, normal liver function is hepatitis B virus carrier; significantly elevated transaminase is hepatitis B. The “two halves” of the hepatitis B virus is the same as that of the hepatitis B virus, but the liver function is normal. How do the markers in the “two halves” change naturally? In fact, 1, 3, 5 “triple positive” is mainly the third E antigen positive, indicating that the hepatitis B virus is actively replicating, contagious, hepatitis may occur; E antigen negative, if the level of virus is still very high, then it must be a viral mutation, easy to recur; if the E antigen along with the virus turns negative, indicating that the hepatitis B infection tends to recover, low replication, rarely contagious, rare, rarely infectious. If the E antigen is negative with the virus, it means that the hepatitis B infection tends to recover, the virus replication is low, it is seldom infectious, and it is rare. Natural infection is often the first “triple positive”, after decades of reduced viral replication, E antigen turns negative, that is, 1, 5 “small two positive”, this time the E antigen turns negative is not very stable; and then the human body’s immune cells to produce E antibody, which becomes 1, 4, 5 “small triple positive”. The half-life of E antibody is only one year, after which it will gradually disappear and become “small two-positive” again, because there are already immune cells that can produce E antibody, and they can still produce antibody when needed, and this time the “small two-positive” is not stable. The “small two-positive” condition is stable. The reversal of “triple positive” refers mainly to the reversal of item 3 (E antigen), and the presence or absence of item 5 (core antibody) is actually not important.