Patient: Hello doctor, I am a 23-year-old girl, childhood examination is hepatitis B triple positive, in a recent re-examination is still triple positive, but aminotransferase is elevated: alanine aminotransferase 48u / l alkaline phosphatase than the reference value of low: is 37u / l viral DNA quantitative 1.609872E + 07 How should I treat the current situation? Is it necessary to take transaminase-lowering drugs? Is antiviral treatment needed? I hope to reply, thank you! Hepatitis B Specialist: Similar questions are often asked. According to the hepatitis B treatment guidelines of the annual liver conferences, antiviral treatment is not recommended for aminotransferases less than 80 U/L, unless, please note, liver puncture biopsy suggests significant hepatocellular inflammation. Therefore, in your case, you can observe for the time being, after all, the transaminase elevation is not much, and it may get better after a rest, and pay attention to the regular review in the future. If you insist on antiviral treatment, it is better to go to the hospital for liver puncture biopsy.