Total bilirubin includes indirect bilirubin and direct bilirubin, collectively known as bilirubin, and is one of the indicators to determine whether the liver and biliary tract are normal. High total bilirubin and indirect bilirubin generally suggest various causes of jaundice, which may be a normal physiological phenomenon or may be caused by liver and biliary diseases, etc. 1. Neonatal jaundice: When the serum bilirubin of newborns exceeds 5-7 mg/dl, jaundice visible to the naked eye can appear, and more than 80% of normal newborns can show this symptom, most of which are physiological jaundice and can disappear after 1 week. A small proportion is pathological jaundice, which can be treated with blue light therapy, medication, etc.; 2, hemolytic jaundice: such as thalassemia, hereditary spherocytosis, etc., which requires medication or even splenectomy treatment; 3, cholestatic jaundice: common in hepatitis and cirrhosis, gallstones, etc., where the patient has poor bile drainage and bilirubin reflux into the blood, thus causing jaundice; 4, other factors: including hyperthyroidism Therefore, it is necessary to further improve the examination, clarify the cause, and then carry out the corresponding treatment.