There are various methods of local inactivation after lesion scraping and grinding drill treatment, including phenol inactivation, liquid nitrogen freezing, hydrogen peroxide inactivation, zinc chloride cautery, argon knife cautery, and hypertonic saline inactivation. The effects of various inactivation methods have been reported differently. At this stage, there is no unanimous understanding of the effect of inactivation methods after tumor curettage, and the choice of various methods in clinical practice is mainly based on the personal experience and habits of the operators. In this paper, we mainly review the literature on the use of inactivation methods used for post-scraping giant cell tumor lesions of the extremities, and evaluate and analyze the advantages and disadvantages of various methods in order to understand the current status and treatment effects of commonly used inactivation methods, especially the recurrence situation, and provide reference for the clinical selection of local inactivation methods for post-scraping giant cell tumor of the bone.