Hypertension is a systemic disease characterized by a sustained increase in systolic and/or diastolic blood pressure in the arteries of the body circulation. In recent years, due to rapid socioeconomic development and changes in people’s lifestyle, the incidence of hypertension has been increasing year by year. Hypertension has a slow onset, a long duration, recurrent attacks, and is difficult to heal, in line with the characteristics of Chinese medicine “long-standing disease into the liao” and “long-standing disease into the blood”. Ye Tianshi said that “long-onset and frequent attacks are bound to hurt the luo, which is the place of blood collection, and long-onset diseases will be stasis closed”. Therefore, with the development of hypertension, there is bound to be long-term disease into the luo, blood stasis. Therefore, the method of activating blood circulation and removing blood stasis is closely related to hypertension. Hypertension is mostly due to atherosclerosis, stenosis, atheromatous plaque formation in the walls of the arteries, and increased blood viscosity, causing blood rheology and microcirculatory disorders, changes in coagulation function, etc. These are all closely related to blood stasis, and hypertension is mostly accompanied by heart, brain and kidney complications, and is associated with spasm and occlusion of heart, brain and kidney vessels, resulting in “blood stasis”. Blood stasis is an important pathological mechanism of hypertension. Blood stasis affects the development of hypertension, so the application of blood stasis treatment can more effectively target the pathological mechanism of hypertension and improve the efficacy of Chinese medicine in treating hypertension. Activating blood circulation and removing blood stasis generally has the application of dilating peripheral blood vessels and increasing blood volume in organs. Activating blood circulation and removing blood stasis can improve microcirculation and the viscous state of blood, resulting in reduced peripheral resistance and lower blood pressure. Modern studies have confirmed the role of blood activation and stasis removal prescriptions in improving hemodynamics, microcirculation and vascular endothelial function. Therefore, treatment with activating blood circulation and removing blood stasis on the basis of evidence-based treatment can optimize the antihypertensive effect, alleviate clinical symptoms, reduce target organ damage, and improve the long-term prognosis of hypertension.