The possible nature of malignant tumors in the hepatoportal region include hepatocellular carcinoma, cholangiocarcinoma and gallbladder cancer. 1. Hepatocellular carcinoma: Hepatocellular carcinoma is the most common primary hepatic malignant tumor in clinic, originated from hepatocytes. When the tumor is located in hepatoportal, it can compress the bile duct and cause jaundice, which needs to be differentiated from other hepatoportal malignant tumors. 2. Cholangiocarcinoma: cholangiocarcinoma refers to malignant tumors located in the extrahepatic bile ducts, which can be divided into upper, middle and lower cholangiocarcinoma according to their locations, among which upper cholangiocarcinoma is also known as hilar cholangiocarcinoma, which accounts for 50~70% of all cholangiocarcinomas. 3. Gallbladder cancer: gallbladder cancer tumor can gradually increase in size and form a mass in hepatoportal area, invade portal vein, hepatic artery and other structures, and at this time, patients are mostly in the advanced stage of gallbladder cancer. It is recommended that patients should go to the hospital as soon as possible to consult professional doctors to formulate scientific and reasonable treatment plan and get treatment as soon as possible when they find malignant tumors in the hepatoportal area.