As elderly tumor patients are old, weak and have poor organ reserve function, many patients’ families and even a few doctors have given up chemotherapy for such patients, which is not scientific. Chemotherapy is an essential part of the overall treatment plan for most malignant tumors. Excessive chemotherapy should be firmly avoided, and the mentality of refusing chemotherapy because of choking is equally undesirable. When planning chemotherapy for elderly patients, the physiological characteristics of the elderly must be taken into account. However, age itself is not a contraindication to chemotherapy and an absolute factor affecting the prognosis. The key is to evaluate the overall status of the body scientifically and accurately before treatment, that is, to make a comprehensive evaluation of the physiological characteristics, disease characteristics, mobility, cognitive ability, past medical history, nutritional status, comorbidities, etc. of elderly individuals. In addition, standardized health education should be conducted to improve patients’ and families’ compliance with chemotherapy. If the patient’s physical condition and organ function are good, standard chemotherapy regimen can be given; if the patient is combined with two or more other diseases, chemotherapy should start with low dose and gradually increase the dose, or adopt a split dose and prolong the cycle; for patients who are weak and have three or more comorbidities, the patient can choose drugs with lower side effects and adopt individualized chemotherapy regimen with low dose and long cycle. While using chemotherapy drugs, we should pay attention to protect the liver, lung, kidney and bone marrow hematopoietic function of patients, and we can also use some auxiliary Chinese medicine to support the essence, which can also correct the imbalance of yin and yang qi and blood, reduce the side effects of chemotherapy, improve the general condition and prolong the survival time.