Spontaneous urticaria is generally categorized into acute spontaneous urticaria, chronic spontaneous urticaria and so on, which can be treated by oral medication as well as by way of medication. 1. Acute spontaneous urticaria: the onset of the disease is generally more acute, the appearance of the size of the red masses, a few minutes to a few hours, the masses gradually disappear, do not leave traces of the skin lesions last no more than 24 hours, the serious patients will appear panic, nausea, you can take antihistamine medication, such as cetirizine hydrochloride tablets, loratadine tablets, and so on. 2. Chronic spontaneous urticaria: generally refers to the disease episodes for more than 6 weeks, the symptoms will be relatively mild, but will recur, and more or less wind puffs. Take cetirizine, ebastine and other anti-allergy drug treatment, but also discretionary hydroxychloroquine, tretinoin and other oral. After controlling the symptoms, it is appropriate to continue to use drugs to maintain the treatment, and gradually reduce the amount until the drug is discontinued. Spontaneous urticaria usually have to stay away from allergens, to prevent recurrence, and at the same time follow the doctor’s instructions to actively treat, the above drugs need to be used under the guidance of a doctor.