The presence of a cough that is really unbearable at night indicates that the cough is very violent and it is possible to use loratadine appropriately. Nocturnal cough is very pronounced and is commonly associated with asthmatic bronchitis, bronchial asthma, cough variant asthma, where the airways appear in a hyper-reactive state with marked congestion, edema, and exudation of inflammatory secretions. Nocturnal cough affects one’s sleep and has a bad impact on one’s quality of life. Loratadine is a second-generation class of H1 receptor antagonists that inhibit allergic reactions in the airways and can reduce the pathological state of edema and congestion in the airways. Proper administration of loratadine can reduce the symptoms of cough and its side effects can cause drowsiness and sleepiness, which happens to facilitate sleep to some extent.