1. mFOLFOX6 regimen dosing schedule: Oxaliplatin 100 mg/m2 iv gtt (2h)d1 Calcium folinate 400 mg/m2 iv gtt (2h)d1 Fluorouracil 400 mg/m2 iv d1 Fluorouracil 2400~3000 mg/m2 iv gtt (46h continuous)d1 After the patient’s postoperative outpatient review and assessment 3~4 weeks The first chemotherapy can be administered, and if there is no special significant discomfort, thereafter, regular chemotherapy will be administered according to this protocol. It is recommended to repeat every 2 weeks for a total of 12 chemotherapy sessions. 2.FOLFOX4 regimen Oxaliplatin 85 mg/m2 iv gtt d1 Calcium folinate 200 mg/m2 iv gtt d1 Fluorouracil 400 mg/m2 iv d1, d2 Fluorouracil 600 mg/m2 iv gtt (continuous 22h) d1, d2 Patients can have the first chemotherapy after outpatient review and assessment 3~4 weeks after surgery, and if there is no special significant discomfort, the first chemotherapy can be administered according to this regimen. Thereafter, regular chemotherapy will be administered according to this protocol. It is recommended to repeat every 2 weeks for a total of 12 chemotherapy sessions. 3.FOLFOX regimen dosing schedule: Oxaliplatin: 100 mg/m2 iv gtt(2h)d1 Tetrahydrofolate: 200 mg/m2 iv gtt d1~d5 5-Fu: 500 mg/m2 iv gtt d1~d5 The first chemotherapy is feasible after outpatient review and assessment of the patient’s condition 3~4 weeks after surgery, if there is no special obvious discomfort, thereafter, follow this regimen regularly. Chemotherapy. It is recommended to repeat every 4 weeks for a total of 6 chemotherapy sessions. 4. 1) CapeOX (XELOX) regimen Oxaliplatin 130mg/m2, iv gtt, d1 Capecitabine (Xeloda) 850~1000mg/m2, bid, po, d1~14 Repeat once every 3 weeks. 2) Capecitabine (alone) regimen Capecitabine (Xyroda) 1250mg/m2, bid, po, d1~14 Repeat every 3 weeks. 5. Hospital discharge procedure: Patients are given a preliminary estimate of the next chemotherapy start date by moving back 2 or 4 weeks from the previous chemotherapy start date. Four days prior to this date, you will be seen in the outpatient clinic to review your blood work, return your lab results to the ward, and make an appointment for hospitalization. The ward physician will try to schedule your admission to chemotherapy on time. On the day of admission, patients should check in on an empty stomach. If the results are normal, chemotherapy will be administered in the afternoon of the day of admission. On the first day of chemotherapy, the principle of inpatient observation should be strictly observed, and patients should not take leave to go home. After the end of intravenous treatment on the first day of chemotherapy, the patient will be given chemotherapy drugs pumped for 44-46 hours. At this time, patients can choose whether to be hospitalized or observed at home, depending on their condition. After the 5-Fu solution has been completely pumped, routine blood tests and liver and kidney function should be repeated and further managed according to the results. If you choose the FOLFOX regimen, you will need to be hospitalized for 5 days. If the blood tests and liver and kidney function are normal on the 5th day after the drip, you will be discharged on the same day or on the 2nd day. If the patient’s blood test results are significantly abnormal on the day of admission, such as a significant decrease in white blood cells or an increase in transaminases, then whitening therapy or liver-protective therapy will be required. The chemotherapy will be started only after the results of white blood cell and liver function are normalized after treatment. 6, out-of-hospital precautions: Because most of the adverse reactions reported by oxaliplatin are myelosuppression, gastrointestinal reactions, neurotoxic reactions, 5-Fu adverse reactions are mostly gastrointestinal reactions, so patients should pay close attention to the changes in their condition during the chemotherapy interval outside the hospital, if there is any abnormality, promptly seek medical attention. (1) Bone marrow suppression: Patients should pay close attention to the fluctuation of white blood cells during the chemotherapy interval. Patients are advised to recheck blood routine every 3~4 days after discharge. If white blood cells are found to be lower than 4.0X109/L or central granulocytes lower than 1.5X109/L, prompt consultation should be made and whitening treatment should be given. Also avoid contact with public places to avoid serious systemic infection. (2) Gastrointestinal reactions: Patients may experience gastrointestinal reactions such as nausea and vomiting during chemotherapy. Therefore, it is recommended that patients have a regular and light diet during the inter-chemotherapy period to prevent nausea and vomiting and other uncomfortable symptoms. In case of severe vomiting, patients should be treated with fluid rehydration. (3) Neurotoxic reactions: The main manifestations are sensory impairment or/and abnormal sensation at the end of the limbs. With or without painful spasms, this symptom is usually triggered by cold. The incidence of neurotoxicity due to oxaliplatin has been reported to be 85-95%. Symptoms usually diminish during the intertreatment period but progressively worsen with increasing treatment cycles. If the patient’s symptoms are severe and prolonged, they should be reported to the physician at the time of the next chemotherapy treatment. The physician will use the patient’s specific situation to decide to reduce or suspend the dosage of oxaliplatin.