The causes of splenomegaly are infectious and non-infectious factors. Infectious spleen is mostly seen in bacterial, viral, parasitic, and rickettsial infections, while non-infectious spleen is mostly seen in liver cirrhosis, portal hypertension, hypersplenism, and other diseases that cause it, and related treatment usually requires specific determination according to the etiology of splenomegaly. Infectious splenomegaly 1, bacterial, viral infections: common are typhoid, paratyphoid, rubella, viral hepatitis, etc., can cause splenomegaly, after the infection can be used under the guidance of the doctor to engulf and kill bacteria and viruses; 2, parasitic infection: parasitic infection caused by the spleen mostly seen in schistosomiasis, malaria, etc., parasites in the blood vessels can lead to abnormalities in spleen function, which can lead to splenomegaly. These patients can be treated with praziquantel drugs. Non-infectious splenomegaly 1, cirrhosis: blood return is blocked in cirrhosis, resulting in spleen bruising and enlargement, which can also be manifested as a decrease in blood cells. This leads to obstruction of hepatic reflux, which causes blood retention in the spleen resulting in splenomegaly, and splenomegaly caused by portal hypertension can be treated with some angiotensin or through surgery to reduce portal vein pressure; 3, hypersplenism: hypersplenism is an advanced manifestation of cirrhosis, and hypersplenism can lead to anemia infection and bleeding tendency, and splenomegaly caused by hypersplenism is usually asymptomatic, and treatment can be chosen from drugs to treat the original Treatment can be chosen from drugs to treat the primary disease, and splenectomy can also be chosen clinically; 4. Other: causes of splenomegaly can also be seen in blood diseases such as leukemia and lymphoma, as well as splenic tumors and splenic cysts. In addition, systemic lupus erythematosus, nodular polyarteritis, chronic right heart failure, and Gaucher’s disease can also trigger splenomegaly. The mechanisms causing splenomegaly are relatively complex, and a clear diagnosis is first required in combination with other examination modalities such as peripheral blood tests, abdominal CT, abdominal ultrasound, bone marrow examination, pathogenic examination and spleen aspiration biopsy, followed by relevant general treatment or drug therapy for the primary disease. Patients who are not treated with the primary disease or whose primary disease allows them to be treated with radiation therapy to the splenic area, partial splenic embolization or splenectomy, depending on their condition.