A decrease in blood uric acid but an increase in blood creatinine may be related to pathological factors such as hepatic synthesis abnormalities, glomerular or tubular dysfunction, or physiological factors such as strenuous exercise.
The liver is the main site of uric acid production, and except for a small portion of uric acid that can be further decomposed in the liver or excreted in bile, the remainder is excreted from the kidneys. The decrease in blood uric acid concentration may be influenced by glomerular filtration and tubular reabsorption. Blood creatinine is generally stable in the body, and its metabolic abnormalities may be related to glomerular filtration rate.
A decrease in blood uric acid accompanied by an increase in blood creatinine may be due to a kidney disease, such as glomerulonephritis, which causes tubular or glomerular dysfunction. Hepatitis may affect the synthesis of uric acid in the liver, leading to low uric acid, or the patient may have a combination of renal disease leading to a decrease in glomerular filtration rate and high creatinine.
Strenuous exercise, consumption of large amounts of protein, etc. can also increase blood creatinine, when the uric acid can be normal, low or high.
Decrease in blood uric acid but increase in blood creatinine can also be seen in other reasons, when there are abnormal experimental data, it is recommended to follow the doctor’s instructions for further relevant examinations, with the help of the doctor to clarify the causes, and targeted treatment or therapy.