Pain induced after gastroscopy, if non-invasive induced gastric cramps, is mostly around a few minutes to an hour; if pain is caused by doing some operation, except for the effect of primary disease of the stomach, it may take 1-2 days to recover, but there are large individual differences. Gastroscopy alone, without doing pathology or other operations, is unlikely to induce pain, and most patients do not experience pain. However, it will cause some irritation to the gastrointestinal mucosa and may induce gastrointestinal spasm, especially on top of the original stomach pathology more easily. The spasm usually lasts for a relatively short period of time, several minutes to about an hour, but can recur. If the spasm is induced by a mucosal injury caused by a microscopic operation, such as taking a pathological biopsy, it may last for several hours to several days. In addition, there is also a relationship with the underlying disease of the patient’s stomach, such as gastric cancer, where the patient’s pain induced by stimulation may last for many days and requires treatment of the primary disease to bring about pain relief. The duration of clinically induced pain varies with different underlying diseases of the stomach and whether they are accompanied by operations, and there are also individual differences, but all of them need to be taken seriously.