A large blood pressure difference (also known as pulse pressure) generally refers to a difference of more than 60 mmHg between systolic and diastolic blood pressure, and is commonly seen in the following conditions. The first is atherosclerosis, a condition most commonly seen in the elderly, caused by the poor elasticity of the atherosclerotic vessels, which does not retract in time during the diastolic phase of the heart, thus causing an increase in the pulse pressure difference. For this condition, it is best to do an ultrasound examination of the carotid artery, lipid tests, etc., and then do targeted treatment according to the results of the examination. The second condition is rheumatic heart valve disease (such as aortic valve insufficiency) or some congenital heart disease, can also appear increased pulse pressure difference. This needs to be clarified by cardiac ultrasound. For these conditions, they can be surgically corrected. The third condition is hypermetabolic disease (such as hyperthyroidism) and anemia, which can also cause an increased pulse pressure difference. The treatment needs to be tailored to these causes. In the fourth case, long-term hypertension leading to heart enlargement or relative heart valve closure insufficiency can also lead to an increase in pulse pressure difference. In this case, first of all, blood pressure should be actively and steadily controlled, and then treated with some drugs that can improve cardiac function. In short, for the increased pulse pressure difference, the cause should be clearly identified in order to do targeted treatment.