There are two different treatment modes of hemodialysis, ultrafiltration alone and dialysis (with ultrafiltration and diffusion), depending on the needs of different conditions. According to the patient’s condition, the hemodialysis program corresponding to different treatment modes at different time periods in the treatment is called sequential dialysis. The fact that we commonly use dialysis in the clinic is dialysis combined with ultrafiltration. Since dialysis is diffusion-based, it affects osmolality and leads to hypotension. Ultrafiltration does not change the osmolality much and has relatively little effect on blood pressure, but is poor at removing toxins. It is the combination of the two that is most effective in uremia. How to combine the most favorable to the patient is the direction of our efforts. Wang Yanhui, Renal Transplantation Department, Zhengzhou People’s Hospital Today I used sequential therapy on a patient, and the results were not bad. The patient has been on dialysis for 9 years, with poor general condition, accompanied by epilepsy, bleeding hemorrhoids can not be opened, severe anemia, thoracic cavity viscous fluid can not be pumped out, etc., weighing only 48 kilograms, 4 times a week on dialysis, each dialysis 3 hours, weight gain between 2-4 kilograms, once a month infusion of red suspension, almost every time the dialysis will fall off the blood pressure, so the dialysis is used to support the high glucose, infusion of the pulse, ginseng and other injections. Today the patient gained 3.4 kg, I first simple dialysis 1 hour, blood pressure maintained at 120/80 mmhg, then simple ultrafiltration for 2 hours, ultrafiltration volume of 3000 ml, during which there is no infusion of high glucose and proprietary Chinese medicines, although the patient finally dropped blood pressure early off the plane, but only 10 minutes earlier, basically to achieve the effect, next time will continue to try. Sequential treatment can help the patient’s blood pressure and dehydration, but ultrafiltration has a poor effect on toxin removal, for young patients and patients with high activity level, it must be prevented from insufficient toxin removal, and if the weight gain is too much, the ultrafiltration volume is too large and still causes the occurrence of hypotension.