What is the pathogenesis of Parkinson’s disease?
It is now generally accepted that Parkinson’s disease is not due to a single factor and that multiple factors may be involved. Genetic factors may increase susceptibility to the disease, but only the combination of environmental factors and ageing, through mechanisms such as oxidative stress and apoptosis, leads to the onset of the disease by massive degeneration of nigrostriatal dopaminergic neurons. Luo Xiaodong, Department of Brain Diseases, Guangdong Provincial Hospital of Traditional Chinese Medicine
Chinese medicine understanding of Parkinson’s disease? Chinese medicine believes that the disease is caused by the deficiency of all the wind, most of the original deficiency and the symptoms are real. “Deficiency” is the key to the disease, often caused by the deficiency of yin and yang qi and blood wind movement, from the wind movement and cause tremors; due to long-term disease into the complex, the veins and channels stasis. The result is yang deficiency, yin deficiency, blood stasis, wind movement, and eventually tremors and stiffness in the limbs.
What are the manifestations of Parkinson’s disease?
²Static tremor.
² Muscle tonicity: some manifest as morning stiffness.
² Motor retardation: lower case syndrome, mask face.
²specific postures: stooped back, panic gait.
² psychiatric symptoms such as depression.
² some other specific symptoms: upright hypotension, greasy face, salivation, numbness and pain, swelling of the lower limbs, dysphagia, speech disorders, urinary frequency and urgency, etc.