Headache is an unpleasant experience, and the incidence of isolated headache (without other associated symptoms) due to intracranial tumors is 2%-16%; when headache is present, it is important to be aware of the need to screen for brain tumors. In patients who clearly have intracranial tumors, an increase in headache is indicative of a worsening intracranial tumor. Relief of headache often means effective treatment. For patients with a history of cancer, be alert to the possibility of brain metastases when new headaches appear. For those who do not know whether they have brain tumor before, they should be aware that headache associated with brain tumor mostly has the following characteristics: 1. Progressive worsening of headache 2. Worse in the early morning or after daytime rest 3. Valsalva maneuver can worsen headache (i.e. deep inhalation followed by tight closure of the vocal cord and then forceful exhalation maneuver) 4. With nausea and/or vomiting The incidence of headache caused by intracranial tumor is 32%-71%. In young patients, tumors with rapid growth and located near the posterior cranial fossa or midline are prone to headache. Headache due to intracranial tumors has no specific features, although progressive worsening is a key feature. The headache is not necessarily located on the same side as the tumor. Tumors adjacent to the skull or dural tissue tend to be associated with ipsilateral headaches. In contrast, high cranial pressure tends to result in diffuse headaches. Intracranial tumors rarely present with headache symptoms alone: there is often a combination of symptoms of neurological deficits (e.g., problems with speech, limbs, cognition, vision, etc.) and convulsions. Therefore, it is important to be aware of the presence of headaches to screen for brain tumors.