I. Principle: Paternal antigens carried by the embryo during pregnancy can stimulate the maternal immune system and a rejection reaction occurs. Sequestering antibodies protect the embryo or fetus from rejection by the maternal immune system. If the mother is deficient in closed antibodies, this results in low homologous immune recognition protection and rejection of the fetus carrying paternal antigens as a foreign body. Therefore, the more closed antibodies, the safer the fetus. Second, the method: immunotherapy must be sure that the blood donor does not suffer from blood-borne infectious diseases (hepatitis B, hepatitis C, AIDS, syphilis), extract the husband or third-party peripheral anticoagulant blood separation of lymphocytes, to the woman for subcutaneous injection, once every three weeks before pregnancy, 3 injections (to avoid menstruation), to determine the pregnancy, once a week, 2 injections, in order to consolidate the line. Third, the role: HLA (that is, closed antibody-negative), the main free treatment, my clinic statistics, can increase the success rate of pregnancy 5-10%, but if you rely solely on the “main free” to protect the fetus, certainly not, the main free after the end of the additional other birth control program can be complete. The main immunization is just to increase the success rate. If you have done the main exemption, no matter what the result of HLA test is, you will no longer carry out the main exemption program. Side effects: the main immunization can lead to immune abnormalities, and the main immunization has infectious diseases (hepatitis, HIV, etc.), blood transfusion reactions, allergic reactions, transplantation anti-host reactions and other side effects. If your antinuclear antibodies are obviously abnormal or very high, main immunization is contraindicated.