Congenital hypothyroidism is generally not curable. Congenital hypothyroidism, or congenital hypothyroidism, is a congenital condition that requires lifelong replacement therapy. Congenital hypothyroidism can be divided into primary and secondary according to the site of the lesion. Primary hypothyroidism is caused by a disease of the thyroid gland itself, with congenital abnormalities in the development of the thyroid gland being the primary cause, and other causes such as impaired synthesis of thyroid hormones and low response of the thyroid gland or target organs. Secondary hypothyroidism is less common, with lesions in the hypothalamus and pituitary gland due to pituitary TSH disorders, commonly due to idiopathic hypopituitarism or developmental defects of the hypothalamus and pituitary gland. Once diagnosed, the disease requires long-term medication to regulate thyroid hormone levels. The drug of choice for the treatment of congenital hypothyroidism is levothyroxine, starting with small doses and gradually increasing them to optimal efficacy. People on this long-term replacement therapy should be monitored for weight and heart function to prevent osteoporosis, pseudotumor cerebri or worsening of coronary atherosclerotic heart disease caused by thyroid hormone overdose.