Right now is the time of grapefruit market, delicious and juicy grapefruit, many people love to eat. However, remind everyone: in taking certain drugs is not to eat grapefruit, otherwise there will be serious adverse consequences. A, what grapefruit can not be taken with drugs? ”After taking drugs and then eat grapefruit is equal to take poison” is not accurate, in fact, not all grapefruit, only grapefruit in the same with some drugs can cause adverse reactions. Grapefruit is also called grapefruit. Grapefruit contains the chemical ingredients naringin, furanocoumarins and flavonoids citrusin, these ingredients will inhibit the drug metabolism enzyme CYP3A4 in the body, eaten drugs stay in the body for a longer period of time, resulting in an increase in the concentration of drugs in the blood. The half-life of the above components in grapefruit juice is about 12 hours, which means that after 12 hours, the effect of grapefruit juice on the body can only be reduced to half. When drinking a glass of grapefruit juice, its effect is sufficient to maintain 3 days. Second, what drugs can not be taken with grapefruit? 1, lipid-lowering drugs do not take with grapefruit: If you eat grapefruit during taking atorvastatin, lovastatin, simvastatin and other lipid-lowering drugs, the possibility of muscle pain, rhabdomyolysis will increase, and in severe cases, acute renal failure may occur. Clinical observations have shown that patients with hyperlipidemia who use a cup of grapefruit juice to deliver a piece of lovastatin will end up with a cup of water to deliver 12 to l5 pieces of lovastatin with lipid-lowering effects, and the patients will have muscle pain and even kidney lesions as a result. 2, antihypertensive drugs do not take with grapefruit: because grapefruit itself also has antihypertensive effect, plus it can also make the blood sample concentration of antihypertensive drugs increased, taking nifedipine, nimodipine, verapamil and other antihypertensive drugs during eating grapefruit or drinking grapefruit juice, as if overdose, so that blood pressure plummeted, light dizziness, panic, weakness, serious angina, myocardial infarction or stroke. The antihypertensive drugs that have significant interaction with grapefruit juice are mainly dihydropyridine calcium antagonists, such as felodipine and nifedipine. Therefore, not all types of antihypertensive drugs can not be eaten with grapefruit. 3, sedative sleeping pills do not take with grapefruit: grapefruit will increase the possibility of diazepam (Valium), midazolam and other drugs cause dizziness and drowsiness, high-altitude workers and drivers should pay particular attention during the medication. 4, birth control pills do not take with grapefruit: the article circulating online said: if a woman taking the pill after sex ate 1 to 2 grapefruit, or before directly with a large cup of grapefruit juice to deliver the pill, then she may become a mother, the reason is that grapefruit hinders the absorption of women on the pill. In fact, this statement is wrong, in fact, the result is the opposite. Birth control pills are mainly hormonal drugs, drugs need to be metabolized by CYP3A4 metabolic enzymes, if and grapefruit or grapefruit juice together, grapefruit in the furanocoumarins will inhibit the body CYP3A4 effect, the human blood concentration will increase, theoretically, the effectiveness and toxic side effects will also be enhanced. 5, cardiotoxic drugs do not take with grapefruit: cardiotoxic drugs, such as antibacterial drugs erythromycin and moxifloxacin, gastrointestinal drugs cisapride and domperidone, anti-allergy drugs tefenadine, etc., do not take with grapefruit, otherwise it may cause dizziness, palpitations, arrhythmias and other symptoms, and even life-threatening. 6, immunosuppressants do not take with grapefruit: grapefruit can make cyclosporine and other immunosuppressants increase blood concentrations, increasing hepatic and renal toxicity. If these drugs are eaten with grapefruit and other fruits for a long time, there is a risk of tumor induction.