In Lu You’s “To the Wine”, there is a poem that says, “Idle sorrow is like flying snow, but it melts away when it enters the wine. A good flower is like an old man, and the cup is empty since a smile”, as if wine can dispel sorrow. For many years, wine has been inseparably linked with people’s lives. Every festive season, friends get together, feast friends and relatives, wine on the table, wine also seems to have become an essential medium for people to socialize and socialize. The poem “The Virtue of Wine” by Meng Jiao of the Tang dynasty comments that “wine is an ancient mirror, which opens the hearts of small people; E sees different manners, and hears different sounds when drunk. The wine has so much merit, and the wine is so deep. The sinner can avoid drunkenness, and this can be the proverb”. The merits and demerits of wine have their own ancient and later to comment, here it is necessary to remind everyone that if you drink too much wine for the holidays, it can lead to hypokalemia, hypoglycemia, and even alcoholic coma, which can be life-threatening in serious cases. In the emergency room, there are some people who have drunk too much alcohol and have weak legs, have difficulty turning over, are sober but cannot move, and are sent to the clinic by family members or friends. However, there are some patients who have severe hypokalemia after drinking and have palpitations, chest suffocation, and emergency electrocardiogram showing malignant arrhythmia, which requires emergency treatment. In addition to hypokalemia, some patients also have hypoglycemia and even coma; some other patients drink alcohol after drinking Pioneer (cephalosporin) antibiotics or drink alcohol after drinking Pioneer (cephalosporin) drugs that lead to disulfiram reaction, respiratory distress, chest pain, sweating, shivering, blood pressure drops, purple lips, abdominal pain, discomfort around the body and many other manifestations, which can be life-threatening if not rescued in time. In particular, some young people binge drinking more than one bottle of liquor, heavy alcohol poisoning, despite active resuscitation still can not wake up soon, a very few patients came too late also lost their lives, this is not alarming, indeed every year there are such cases. When celebrating the festive season, we must pay attention to drinking in moderation. “Just one can be a peace of mind, do not more cups of self-harm body”, advise you not to greedy a glass of wine, lest the day long sickness, especially the usual medication, there are underlying diseases, infusion of antibiotics such as Pioneer patients should stay away from alcohol, so as not to have fun.