Serpentine is medically called herpes zoster, which is caused by varicella-zoster virus infection and has the folk name of serpentine because it occurs mostly in the lower back. There is a possibility of self-healing from serpiginous herpes, and the specific time is related to one’s immunity. Most people recover in 2-4 weeks, but if the patient is immunocompromised, self-healing is less likely. To avoid leaving nerve pain, it is recommended that oral or topical medication be administered as prescribed by the doctor in a timely manner to avoid expecting self-healing. If the symptoms of serpentine are relatively mild, with only blisters on the lower back, and if the patient is relatively young and does not have a significantly lowered immune system, the blisters will gradually crust over after proper rest, and it will take 2-4 weeks for all blisters to completely disappear. During this period, patients should pay attention to maintaining normal work and rest, avoiding late nights and overexertion, keeping the local skin clean, and not scratching the area with their hands. If the symptoms of serpentine sores are heavy, with a band-like distribution and significant pain, and if the patient is older or has a reduced immunity, it is more difficult to heal oneself. Those with severe pain can be treated with additional pain medication, while paying attention to wearing loose clothing to avoid rubbing the local lesion location and causing pain and discomfort. In addition, if painful symptoms persist for more than 1 month, the possibility of postherpetic neuralgia needs to be considered.