Hepatitis C virus (HCV) infection has a high incidence of chronicity, cirrhosis and hepatocellular carcinoma, and is more dangerous than hepatitis B. Interferon (INF), a western drug, is currently the drug of choice for the treatment of hepatitis C, but the complete response rate (CR) is about 45% and the durable response rate (SR) is only 20%, and there are many side effects. In recent years, researchers in China have actively explored Chinese medicine for the treatment of hepatitis C and have made some progress. Zhang Aizhong, Department of Traditional Chinese Medicine and Liver Diseases, Wuhan Medical Treatment Center At present, no TCM typing criteria for hepatitis C have been introduced in China. By studying the clinical syndromes of hepatitis C, TCM experts have provided an objective basis for establishing criteria for the identification and typing of hepatitis C. The clinical characteristics of hepatitis C cases are: (1) blood transfusion is the main way to transmit hepatitis C (2) incubation period varies in length (3) slow onset, symptoms are mainly weakness, poor appetite and abdominal distension (4) dampness is more frequent, and blood stasis blocking evidence is common (5) deficiency is caused earlier (6) liver function recovers faster (7) chronicity tends to be obvious in those with hepatitis C overlapping infection with hepatitis B. A comparative study of chronic hepatitis B and C revealed that hepatitis C patients are older, have deeper latent disease, more moderate pathological response, and are more prone to stagnation of evil toxins and depletion of vital energy than hepatitis B. Therefore, they are more prone to stasis and blockage of ligaments. A TCM specialist conducted a multicenter random sampling to collect 139 cases in Beijing area. Using the 11.0 software package, Kmea cluster analysis was performed on all patients’ symptoms, signs and symptoms, and tongue and pulse, and then principal component analysis was performed on each type to determine the representative symptoms of each type and summarize the evidence types. Results Among the 34 symptoms collected in the survey, the symptoms with a higher rate of occurrence were weakness, stuffy abdomen and distension, and sticky and unpleasant stools. The symptoms with a lower rate of occurrence were cold extremities and chills, night sweats, and scanty urination. In addition to the 5 types of chronic liver (damp-heat, liver-depression, spleen-deficiency, liver-kidney-yin-deficiency, qi-stagnation, blood-stasis, and spleen-kidney-yang-deficiency) established by the National Committee of TCM Hepatobiliary Diseases in 1991, there are also three other conditions: qi-yin deficiency, dampness and toxicity obstruction, and no evidence to identify. A TCM research institute collected 491 cases of hepatitis C from eight provinces, including Xinjiang, Gansu, Yunnan, Hebei, Jiangxi, Jiangsu, Shanghai, and Taiwan, and conducted a frequency analysis of the frequency of all symptoms. The K-class central clustering method was used for cluster analysis and principal component analysis, and with reference to the textbook of Diagnosis of Traditional Chinese Medicine, Fifth Edition, the five types of symptoms were initially classified as damp-heat, liver-depression and spleen-deficiency, liver-kidney deficiency, qi-deficiency and blood stasis, and positive deficiency and evil retention. As mentioned above, the research on the specification of the evidence types is yet to be further developed. The treatment of hepatitis C is also different. Some experts believe that the evil of epidemic and toxin invade the blood, and the toxin and stagnation of blood consume the qi, so they propose the treatment of activating the blood to detoxify the toxin, draining the liver and resolving phlegm, and tonifying the liver and kidney. The detoxification medicine should also be used to detoxify the liver and regulate the qi with the dual role of detoxification and blood circulation, which can prevent the medicine from aggravating the disease due to yin condensation and stagnation, and to supplement the liver and kidney at the right time. Some doctors, based on the analysis of TCM cases, propose to clear the heat and detoxify the toxin, emphasize on supporting the righteousness and supporting the toxin, and pay attention to resolving the stasis and preventing the nodules from becoming cancer. Other experts believe that actual-deficiency-stasis is the pathology of hepatitis C. Clearing heat and relieving dampness, strengthening the spleen and resolving dampness, strengthening the spleen and benefiting the kidney, and activating blood circulation and resolving blood stasis are the keys to treating hepatitis C. Some TCM experts believe that the combination of evidence and disease should be identified. Acute hepatitis C should be treated by clearing heat and detoxifying toxins, using Yin Chen, Gardenia, Scutellaria, Tiger Balm, and White Flowering Serpent’s Tongue Herb for chronic hepatitis C. For chronic hepatitis C, lighter cases should be treated by benefiting qi, nourishing yin, and draining the liver, using Huang Qi, Angelica, Danshen, Fructus Lycii, Shengdi, Mai Dong, Sha Shen, Guaou, and Licorice for chronic hepatitis C. For chronic hepatitis C, heavy cases diagnosed with cirrhosis, using Danshen, Red Peony, Dampi, Angelica, Raw Hawthorn, Chuanxiong, Guaou, Ge Gen, Xu Changqing, and Yu Jin, it is It is advisable to add softening and dispersing products such as turtle plate, turtle nail, mountain nail, Panax ginseng powder and water hyacinth. Clear retreat formula (30g each of raw astragalus, salvia, forsythia, red peony, 15g each of raw shouwu, raw hawthorn, danpi, fried gardenia, dandelion, 10g each of Chaihu, decoction in water, 1 dose daily divided into 2 oral doses. 3 months as a course of treatment. Treatment of chronic hepatitis C 128 cases, the results: 71 cases cured, 36 cases with significant effect, 12 cases effective, 9 cases ineffective, the cure rate of 53.9%, the total effective rate of 92.9%. Some of the doctors used a combination of Chinese and Western medicine methods, western medicine interferon plus Chinese medicine identification and typing grouping formula, Chinese medicine one type one side treatment of hepatitis C, improve the treatment effect and reduce the side effects of interferon. As the main pathogenesis of chronic hepatitis C is heat and toxin stasis, liver and spleen imbalance, both evil real and positive deficiency, treatment should be to cool the blood and detoxify, regulate the liver and transport the spleen as the main method, according to this developed some Chinese medicine formulations (composed of water hyacinth, tiger scepter, rhubarb, red peony, etc.) to treat chronic hepatitis C 32 cases to achieve better results. And a randomized group control study was conducted with 30 cases of interferon combined with virazole and 32 cases of interferon alone in the treatment of chronic hepatitis C. The efficacy of traditional Chinese medicine in the treatment of chronic hepatitis C was observed to be similar to that of the interferon combined with virazole regimen in the near-term efficacy and long-term efficacy (>0.05). Clinical observations revealed that these herbal dosage forms had significant antiviral effects in the treatment of chronic hepatitis C without serious toxic side effects and were well tolerated. The pathogenesis of hepatitis C is complex, and most scholars believe that it is related to dampness, heat, epidemic and toxicity, but what is the relationship between dampness, heat, epidemic and toxicity? What are the mechanisms of changes in the depletion of qi, blood, yin and yang that they bring to the infected organism? How to solve the difficulties in determining the clinical TCM identification and typing criteria? How to apply the randomized double-blind method to improve the credibility of clinical research results, etc., are all questions that have yet to be solved. A large number of practices have proved that the combination of Chinese and Western medicine is effective in the treatment of hepatitis C. It should be given great attention and actively studied.