1, joint swelling or pain: most of the rheumatologic immune diseases have joint symptoms, which can be mild or heavy, short or long lasting, and can be accompanied by local redness and fever, or can only show pain. They may be wandering or fixed, or they may be episodic. It is worth noting that if there is significant swelling of the joint, it is necessary to see a doctor. 2, myalgia muscle weakness: such as dermatomyositis, polymyositis, metabolic myopathy and tumor-induced myopathy can appear this performance. 3, Raynaud’s phenomenon: Raynaud’s phenomenon is the hands or feet turn white when cold or emotional change, get warm or emotional stability after turning red, and finally turn to normal color. Many diffuse connective tissue diseases such as mixed connective tissue disease, systemic sclerosis, systemic lupus erythematosus, etc. can appear this phenomenon. 4.Dry mouth and eyes: Dry mouth and eyes are not only seen in diabetes, use of certain drugs such as antidepressants and urolithiasis, but more often in primary or secondary dry syndrome. 5, lower back pain and alternating hip pain: many patients with ankylosing spondylitis, undifferentiated spondyloarthropathy, etc. can have these symptoms, mainly manifested as pain in the back at night, especially in the second half of the night and wake up, with a sense of morning stiffness, symptoms can be improved after activity. 6, heel pain or other tendon end pain: many seronegative spondyloarthropathies can show these manifestations. 7, multi-system or organ damage: most diffuse connective tissue diseases such as systemic lupus erythematosus, systemic vasculitis, systemic sclerosis, etc. can involve multiple organs or systems throughout the body. 8. Unexplained fever: For long-term fever that is not treated with antibiotics or anti-tuberculosis and tumors are excluded, the possibility of rheumatic immune disease must be considered. 9, recurrent ophthalmia, external genital ulcers and oral ulcers: this manifestation can occur in leukoaraiosis. 10, easy to catch a cold: primary or secondary immune deficiency can appear easy to catch a cold. 11, other manifestations such as nodular erythema, photosensitivity, recurrent thrombosis, joint or muscle stiffness, recurrent auricular swelling and pain, recurrent purulent or bloody nasal discharge, recurrent miscarriage, waxy fingers (toes), local or generalized skin sclerosis, generalized pain with insomnia and cold and fear of cold limbs may be manifestations of some rheumatic immune disease. In short, the manifestations of rheumatic immune diseases are diverse, and the clinical symptoms listed above are only some common manifestations.