If taking one or two drugs can control blood pressure well, there is no need to change the medication frequently. There are several reasons for this: 1. So far, the pathogenesis of hypertension has not been completely clarified, and may be the result of one factor or a combination of factors, and clinicians often choose one or more drugs for treatment based on experience. Blood pressure can be effectively controlled suggesting that the right therapeutic target has been selected, and the selected drug blocks the main link in the patient’s pathogenesis. Blindly changing to another drug, whether it can effectively control blood pressure is difficult to guarantee. 2, there are many kinds of clinically used drugs, due to different pharmacological effects, different bioavailability, different toxic side effects, so each drug shows different antihypertensive properties, some can work quickly, some need 1 to 2 weeks to achieve the most effect, some can only maintain 7 to 8 hours, while some can maintain 24 hours or even longer. Each change of medication requires a process of figuring out from scratch to find the best drug combination and dosage, which may be short, but in some patients may be long, weeks or even months. If the change of drugs is too frequent, the time to figure out will be very long, in such a long time blood pressure can not be effectively controlled, blood pressure will fluctuate from time to time, there may be cardiovascular and cerebrovascular damage to the system, the loss is not worth it. 3, now regular hospitals, pharmacies sold drugs, are approved by the relevant state departments, but also through the process of elimination of the best and the worst, can be saved more than fine, some have been in clinical use for more than a decade, decades, evidence-based medicine is sufficient, there are a large number of clinical trials to confirm and many patients use, the efficacy is reliable, less toxic side effects, can be assured of long-term use. There is also no evidence that a certain antihypertensive drug will develop resistance. As long as the regular use, the efficacy of using a year or more after the beginning of the use of the efficacy is not significantly different, so there is no need to worry about the problem of drug resistance. 4, some people worry that if they use such a good drug now, there will be no more drugs available when their blood pressure is higher, and they hope to use imported drugs when their blood pressure is high, and replace them with domestic drugs after their blood pressure is controlled. In fact, this is not the case. As people’s research on the pathogenesis and clinical treatment of hypertension continues to deepen, new theories are emerging, new therapeutic targets will emerge, and correspondingly drugs for these new targets will emerge. There will still be many quality drugs for doctors and patients to choose from. Therefore, there is no need for hypertensive patients to change their medications frequently.