Angong Niuhuang Wan Ointment is a traditional Chinese medicine formula, which has been applied for a long time, with good safety and rare serious adverse reactions. The main ingredients are niuhuang, buffalo horn concentrated powder, artificial musk, pearl, cinnabar, xionghuang, huanglian, baicalin, scutellaria, gardenia, yujin and ice chips. It contains musk and staminaria, which should be taken with caution by pregnant women. The prescription contains cinnabar and staghorn, long-term overdose, the liver and kidney liver and kidney function has an impact. Niu huang, buffalo horn, Huanglian, gardenia, scutellaria and other drugs are cold, easy to damage the spleen and stomach, and should be used with caution by those with weak spleen and stomach. There is a reported 12.5% probability of diarrhea and 12.5% probability of loss of appetite and nausea [1]. Some patients may experience rash and gastrointestinal discomfort. In addition, this product is designed for heat shutdown and should not be used for cold shutdown. During the medication period, it is advisable to eat a light diet and avoid spicy and oily products to avoid fueling fire and producing phlegm. As there is no special antidote for Niuhuang Detoxification Pill, remember not to apply it blindly. In the course of treatment, if cold extremities, pale face, cold sweat, weak pulse and change from closed evidence to off evidence, the medicine should be stopped immediately.