An Gong Niu Huang Wan was firstly described in Wu Jian Jian’s “Wenzhi Zhuan Zhi Zhi” in Article 16 of the Upper Jiao Chapter. The composition of the formula is Niu Huang, Yu Jin, Rhinoceros Horn, Huang Lian, Scutellaria, Gardenia, Zhu Sha, Xiong Huang, Plum Pieces, Musk, Pearl, Golden Foil Coat and Old Honey. The main efficacy of the herb is that it is mainly composed of niu huang, which clears heat and detoxifies the body, and musk, which aromatically opens the orifice. In addition, it is combined with Yu Jin and Xiong Huang to enter the heart meridian to cool the heart and open the orifices; Niu Huang is combined with Huang Lian, Scutellaria Baicalensis and Mountain Gardenia to break the fire. The whole formula works together to open the orifices, clear heat and detoxify. The effects are: 1. High fever and coma caused by various reasons. Patients with high fever and coma are in dangerous condition, and Angong Niuhuang Pill has the function of clearing heat and detoxifying, opening the orifices and awakening the mind, so it can be used as an emergency product for patients with high fever and coma whose causes have not been identified or have not been identified in time. It can be used as an emergency product for patients with high fever and coma who have not yet identified the cause or the cause has not been identified in time. This includes high fever and coma caused by the acute stage of stroke; high fever and coma caused by heavy infectious diseases, including sepsis; viral encephalitis; severe pneumonia; 2. Angong Niuhuang Wan can improve the clinical efficiency of neurological severe diseases such as intractable epilepsy and pediatric convulsions, which is a major breakthrough in the treatment of neurological severe diseases. 3.