Breast cancer patients with bone metastases have no effect on tumor indicators after taking painkillers. Patients with breast cancer bone metastasis can take painkillers appropriately if the pain is more obvious. Taking painkillers for breast cancer bone metastasis patients will not induce or aggravate the tumor, so it will not affect the changes of tumor indicators. Tumor indicators are produced by tumor tissues, and doing the examination of tumor indicators can understand the condition of the tumor. Tumor indicators include alpha-fetoprotein, carcinoembryonic antigen, prostate-specific antigen, glycocalyx antigen, carcinoma antigen, squamous cell carcinoma antigen, and tissue polypeptide antigen. The side effects of common painkillers can cause stomach pain, loss of appetite, peptic ulcer, bleeding and perforation, liver and kidney function damage, etc. The common side effects of morphine opioid painkillers include skin itching, nausea and vomiting, abdominal distension and constipation, and addiction, etc., which generally do not affect the tumor indicators. Patients with breast cancer bone metastasis should use painkillers under the guidance of a physician’s interview, and patients should not use drugs on their own to avoid adverse results.