In recent years, for women who have difficulty conceiving or are not pregnant, physicians often recommend testing for “Anti-Mullerian Hormone” (AMH) because AMH is more reflective of the true age of the ovaries and understands the stock of follicles! Being able to predict success rates before IVF treatment is a “miracle” that every patient and physician dreams of, and various indicators and models have been tried but are not satisfactory. Anti-Mullerian hormone (AMH) is a biomarker that has emerged in recent years, secreted by granulosa cells of small sinus follicles, reflecting ovarian reserve function and predicting ovarian responsiveness to stimulation with ovulation-promoting drugs. Ovarian reserve is one of the key factors in determining the satisfactory outcome of IVF. Assessing ovarian function and predicting ovarian responsiveness before performing controlled ovulation stimulation is a prerequisite for a comprehensive and objective evaluation of IVF feasibility and individualized drug use. Anti-Mullerian hormone (AMH) has become an important and valuable predictor after age and sinus follicle count (AFC). The use of serum AMH for predicting ovarian hyporesponsiveness has been confirmed by an increasing number of studies. Since different studies have adopted different diagnostic criteria for low response internationally, AMH diagnostic cut-off values ranging from 0.99 to 3.65 ng/ml have been reported. Analysis of 5,283 IVF cycles at the Reproductive Hospital of Shandong University showed that AMH <1.22 ng/ml can be used as a threshold value for predicting ovarian hyporesponsiveness in Chinese women. Ovarian hyperresponsiveness, represented by ovarian hyperstimulation syndrome (OHSS), is one of the common complications during ovulation promotion, with severe being the most aggressive. Young infertility patients with good ovarian reserve, especially women with PCOS, are at high risk of OHSS. AMH is more accurate than FSH and AFC in predicting hyperresponsiveness, with a diagnostic threshold of >3.75 ng/ml. When clinicians design ovulation promotion protocols for patients, they usually refer to the woman’s age, basal FSH value, body mass index (BMI), sinus follicle count (AFC ) and other comprehensive indicators to determine the initiation dose of ovulation-promoting drugs. Now with AMH as a reference to guide the dose of medication, the safety and efficacy of ovulation promotion has been effectively improved. In a retrospective study in the UK, comparing a study group with an AMH-based stimulation regimen to a control group with a basal FSH-based regimen, the incidence of OHSS and cycle cancellation rates decreased in the AMH group compared to the FSH group, and pregnancy and live birth rates increased significantly, while reducing the financial burden on patients. Although AMH is considered to be one of the best predictors of ovarian responsiveness, there is no uniform diagnostic cut-off value at home or abroad. AMH represents the number of eggs, but not their quality AMH only represents the number of eggs, not their quality, which is related to age. For example, if the AMH value is very low, but the patient is young and has good quality eggs, even if the number of eggs is low, there is still a chance of pregnancy; if the patient is older, the quality of eggs will be poor, and even if the AMH value is good, the pregnancy rate will still be affected! Advantages of AMH in predicting ovarian function AMH has the following advantages compared to other methods of predicting ovarian function: 1. As age increases, ovarian function will gradually decline and AMH values will also decline. Therefore, of all the methods used to detect ovarian function, AMH values are the earliest to screen for ovarian failure. 2. The concentration of AMH is not affected by the menstrual cycle, so the concentration of blood drawn during any period is equally stable. 3, AMH test for young women can screen out women with early ovarian failure so that they can be treated in real time to avoid wasting time and waiting until it is too late to plan for a baby. AMH test first! Even if you are still young, if you find that your AMH number is too low and your ovaries are close to 40 years old, do you want to take your time? So no matter how old you are, AMH should be measured first! Get pregnant while you still have eggs! The AMH level is not necessarily related to age. Young women may also have a low AMH level and therefore may stop menstruating early.