Hepatic hemangioma is a common benign tumor of the liver. With the improvement of medical imaging equipment and diagnostic level, as well as the general emphasis on the requirement of health checkups, the number of hepatic hemangiomas detected through physical examinations is increasing, and almost all hemangiomas occurring in the liver are spongy hemangiomas, with the hepatic artery being its main blood supply artery. Surgery was the traditional treatment of choice until the 1990s, and its efficacy was confirmed. It has been more than 10 years since we first proposed the application of Pingyangmycin iodine emulsion (PLE) embolization and sclerosis for hepatic hemangioma at the National Interventional Radiology Symposium in Beidaihe in 1996, and through more than 10 years of clinical application and observation, this method is minimally invasive, safe, reproducible, and has satisfactory efficacy without serious complications. By using Seldinger’s technique, the femoral artery is punctured, the hepatic artery is cannulated and firstly, the diagnosis is further clarified by imaging, the number and size of hepatic hemangioma, the condition of abnormal blood sinusoid and blood supplying artery in the tumor, etc., and the appropriate dose of Pingyangmycin (PYM) and super-liquidated iodine oil (Lp) is selected to make emulsion (PLE), and PLE is injected into the abnormal blood sinusoid of the tumor through the catheter under fluoroscopy. The PLE is injected into the abnormal blood sinusoid under fluoroscopy, and the hepatic hemangioma is treated by releasing pinyamycin to act on the endothelial cells of the blood sinusoid to sclerosis and occlusion.