Vaccination with the New Crown vaccine can reduce the risk of infection to some extent, but no vaccine can be guaranteed to work 100% of the time for everyone. The protective effect of the vaccine can be divided into three levels: primary prevention is against infection, which protects the vaccinated person from infection; secondary prevention is against morbidity, which keeps mild illness from becoming severe or even progressing to death; and tertiary prevention is against transmission, where there are a few symptoms but the amount of virus in the body is so small that it is difficult to transmit to others. The current position of the new crown vaccine is secondary prevention, that is, after receiving the new crown vaccine there is still a possibility of being infected by the new crown virus or even developing the disease, but the available research results show that the vaccination is mostly asymptomatic or light cases after infection, and the risk of serious illness and death is greatly reduced, and the effect is still very significant. The mutation of the virus has been a high concern for the state and vaccine R&D and production units. Our vaccine has been clearly shown to provide good protection against common prevalent strains, and from the global monitoring of the mutation of the neo-coronavirus, there is no evidence that the virus mutation will render the existing neo-coronavirus vaccine ineffective. A special reminder is that daily protection is still needed after vaccination. You should wear a mask when you go out, avoid crowded places, keep your home ventilated and disinfected, and exercise regularly to improve your physical fitness. Only with multiple protections can we minimize the infection of New Coronavirus and maximize the protection of normal life.