Diabetic patients with abdominal distension and gastrointestinal dyspepsia should first clarify the cause of the disease, and then follow the doctor’s prescription for the cause of the disease. Considering that it may be due to the complications of diabetes mellitus, it is necessary to actively control blood glucose in the treatment, taking methylcobalamin, epalrestat and other nutritive nerve drugs. It may also be caused by the side effects of hypoglycemic drugs, need medication, adjust the hypoglycemic drugs if necessary. 1. Treatment of primary disease: diabetic patients with abdominal distension and gastrointestinal dyspepsia. Consider that it may be due to long-term poor glycemic control, resulting in the development of autonomic neuropathy, which affects the gastrointestinal system, showing symptoms such as delayed gastric emptying, abdominal distension, gastrointestinal dyspepsia, nausea, vomiting and so on. In this case, diabetic patients should control their own blood glucose level and take nutritive nerve medications such as methylcobalamin and Epalrestat if necessary. 2. Medication and adjustment of medication: diabetic hypoglycemic drugs, such as metformin, acarbose and other hypoglycemic drugs, one of the most common side effects is the emergence of gastrointestinal reactions, such as abdominal bloating, gastrointestinal dyspepsia, constipation, diarrhea, etc., the adverse reaction of the patients, can be prescribed to replace other hypoglycemic drugs. Diabetic patients with abdominal distension, gastrointestinal indigestion, it is recommended to consult a doctor in a timely manner, under the guidance of a professional doctor standardized treatment.