Acute exacerbation of chronic bronchitis is usually treated with medications, such as: antibiotics such as levofloxacin, cough and phlegm medications such as aminobromine hydrochloride, as well as antispasmodic and asthma medications such as albuterol aerosol. 1. Antibiotics: Cefuroxime, Levofloxacin and other drugs can be chosen under the guidance of the doctor, which can gradually relieve the condition. 2. Cough and phlegm medicines: during the acute attack, there may be cough and phlegm symptoms, can be under the guidance of the doctor to take the compound licorice combination as well as the hydrochloride aminoglutethimide and other drugs to control the condition. 3. Antispasmodic and asthma drugs: in the case of acute attacks of bronchitis, there may also be severe symptoms of wheezing, at this time you can follow the doctor’s instructions to use β2 agonists and other drugs, such as salbutamol aerosol and terbutaline sulfate aerosol, through the inhalation of such drugs to achieve the effect of asthma. There are many ways to treat acute exacerbation of chronic bronchitis, it is recommended to go to the hospital for examination, according to the severity of the disease and follow the doctor’s instructions for treatment.