After aortic coarctation replacement with artificial blood vessels and mechanical valves, as long as the patient recovers well, he/she is usually able to receive the new coronary vaccine. After undergoing surgery, as long as the patient has recovered well, no serious surgical complications, no obvious discomfort, and the body’s immunity and resistance have returned to their pre-surgical state, this situation can be considered for receiving the new coronary vaccine. In order to be on the safe side, it is recommended that the patient undergoes a cardiac ultrasound before receiving the new crown vaccination to make sure that he/she is in good physical condition, and that he/she receives the vaccination with the consent of the specialist. The most common adverse effects of the vaccination include redness, swelling, pain, and nodules at the site of the vaccination, as well as the possibility of fever. There are some risks associated with the vaccination, and patients are advised to consult their specialists for further information.