Anesthesia is the implementation of surgery or diagnostic examination operations as the elimination of pain, to ensure patient safety, to create good surgical conditions and various methods, also used for pain control [1]. With the development of society, people’s requirements for surgical treatment are getting higher and higher, and consequently, the requirements for anesthesia have also been raised to a higher level, so the selection of appropriate anesthetic drugs before surgery is a key factor to ensure the smooth operation. 1, Data and Methods 1, 1 Study subjects: 120 patients who underwent surgical treatment in our hospital from May 2014 to October 2014 were selected as study subjects, of which 54 were male and 66 were female; their ages ranged from 19 to 69 years old, with an average age of (47±7.2) years old; their weights ranged from 52 to 74 kg, with an average weight of (60.12±1.34) kg; 120 of them were anesthetized before surgery. ) kg; blood gas analysis of 120 patients had different degrees of abnormality at the preoperative examination, and was accompanied by different degrees of hypoxia, carbon dioxide concentration and pulmonary hypoplasia. 120 patients had no history of serious liver or kidney diseases, no history of long-term opioid use, no history of related drug dependence diseases, and no history of psychiatric disorders at the preoperative examination. 1,2 Research method: 120 patients who underwent surgery were randomly divided into control group and observation group, 60 cases in each group, there is no significant difference between the two groups in terms of gender, age, weight and other aspects, P<0.05, no statistical significance, and it is comparable. 1,3 Clinical treatment methods: The control group was given the appropriate amount of fentanyl, midazolam, vecuronium bromide, and compound anesthesia with propofol sedation according to the patient's body mass before surgery. The observation group applied remifentanil for intravenous anesthesia before surgery, followed by remifentanil and propofol for maintenance anesthesia. 1,4 Observation indexes [2]: hemodynamic indexes [HR, oxygen saturation, diastolic blood pressure (DBP), systolic blood pressure (SBP)], awakening time, extubation time, and adverse reaction rate of patients in two groups. 1,5 Statistical methods: SPSS17.0 statistical analysis software was applied to statistically analyze the data, and the count data were expressed as rate, and the measurement data were expressed as mean ± standard deviation. Comparison between means was analyzed by t-test, and the relationship between two variables was analyzed by correlation data, and the difference was statistically significant at P<0.05. < span=""> 2. Results 2.1 Comparison of hemodynamic indexes between the two groups of patients: after the statistical comparison of HR, DBP, SBP before surgical anesthesia and oxygen saturation during surgery between the two groups of patients, the difference was not significant and had no statistical significance. 0.05, the difference was significant and statistically significant. 3, Discussion Remifentanil, belonging to the opioid class of drugs, is a new type of analgesic currently used in clinical practice, into the body to reach the blood-brain equilibrium in only 1 minute, its structure contains the ester bond so that remifentanil in the tissues and plasma can be non-specific solubility, about 1 minute can reach the effective concentration to play the role of analgesia, the role of maintenance time between 5 to 10 minutes [3]. The effective biological half-life of the drug is about 3-10 minutes and is independent of the dose and duration of administration. Remifentanil is mainly hydrolytically metabolized by non-specific esterases in plasma and tissues, and is not affected by plasma cholinesterase and anticholinesterase drugs and hepatic and renal function, as well as by age, weight, and gender [4]. Therefore, after adopting the anesthesia method of preoperative remifentanil intravenous anesthesia and intraoperative remifentanil and propofol maintenance anesthesia in the observation group, the incidence of adverse reactions such as nausea and vomiting was significantly controlled. After the metabolism of intraoperative injected remifentanil, 95% of the metabolites were excreted through urine, which reduced the accumulation of drugs in the body, and achieved the purpose of letting the patients wake up and move around early, so that the awakening time of the patients in the observation group was significantly shorter than that of the control group [5]. The present study shows that remifentanil has achieved good clinical therapeutic effect in surgical anesthesia, and shortened the awakening time and short extubation time, reduced the rate of adverse reactions, and is worthy of promotion and application in the clinic.