After a long time, general anesthesia patients postoperative anesthesia awakening period, before and after the removal of tracheal tube, the patient showed extreme irritability, resulting in the patient’s heart rate is too fast, blood pressure is too high, pain intensification, the incision is cracked, respiratory depression, generalized muscle tension, chills, and the body’s oxygen consumption increases, and even the patient fell down the traumatic injuries, the removal of a variety of drainage tubes, and other accidents. This leads to serious distrust and dissatisfaction of the family members towards the doctors, and at the same time brings psychological pressure and unhappiness to the medical staff and anesthesiologists themselves, and the patient’s irritability before and after the postoperative extubation is even regarded as the standard of anesthesiologist’s anesthesia level by his colleagues. Therefore, in recent years, I have studied more than 300 cases of general anesthesia patients of upper abdominal surgery, the content is about how to reduce the rate of general anesthesia patients’ irritability before and after extubation. First of all, we analyze the causes of patient postoperative irritability: First, the incision and injury site pain: pain is the most important reason for patient irritability, so adequate intraoperative analgesia is the main task of reducing patient irritability. Excessive sedation and incomplete muscle recovery: the control of general anesthesia is jointly accomplished by analgesia, sedation and myorelaxation, which can constitute the optimal depth of anesthesia only if they are reasonably coordinated and reasonably reduced during the awakening period, and dyspnea and hypoxemia can trigger the occurrence of patient’s agitation. Stimulation of various drainage tubes: the stimulation of drainage tubes can trigger the patient’s irritability, but incomplete awakening from anesthesia is the main factor of such irritability. Fourth, intraoperative anesthesia control is unreasonable: or the patient has the phenomenon of intraoperative knowledge, which can lead to the occurrence of the patient’s systemic stress reaction and the patient’s psychological anger. Respiratory obstruction: tracheal intubation injury or sputum and other foreign objects blocking the airway, etc., which can trigger the patient’s irritability. Electrolyte disorders, acid-base imbalance, hypothermia, severe imbalance of blood volume. According to the above six causes of irritability, combined with more than 300 clinical cases, I summarized the following anesthesia program (upper abdominal surgery), appropriate communication with the patient before anesthesia to enhance the patient’s trust in the anesthesiologist, try to eliminate the intramuscular injection of preoperative drugs, and when necessary to use the drugs in an intravenous manner. (Excluding patients over 75 years of age and frail patients) Preoperative static injection of 5 mg dizocin injection, as an over-the-counter analgesia, induction of anesthesia with imidazole 3 mg, isoproterenol 80 mg – 200 mg, fentanyl 0.2 mg, celine 4 – 6 mg (atracurium 6 – 10 mg), the end of the intubation to give remifentanil micropumping, according to the blood pressure and heart rate rate control between 120 to 200 micrograms At the same time, sevoflurane was inhaled, and the concentration was controlled between 1 and 3% according to the blood pressure and heart rate, fentanyl was injected intravenously at 0.1 mg 2 minutes before the start of the operation, and isoproterenol was given at 20—50 mg according to the blood pressure and heart rate. Intraoperatively, according to the recovery of muscle strength, muscle relaxants were given at appropriate times. 40–60 minutes before the end of the operation, 5 mg of diazoxide was given, the inhalation of 7 halothane was stopped, and the micro pump was used to inject isoproterenol at the rate of 100 to 250 mg per hour continuously, and the dose of remifentanil was reduced by 30%, and it was continuously injected until 10 minutes before the extubation. According to the above anesthesia methods, the incidence of anesthesia was reduced from 30% to 5%.The patient was basically fully awake 10 minutes after surgery, could effectively answer the anesthesiologist’s directive questions and answers, and was able to safely remove the endotracheal tube. The above anesthesia methods may not be the optimal combination, because general anesthesia is affected by a variety of factors, please continue to work hard to conclude a safer, more reasonable and more effective general anesthesia methods.