Many patients with epilepsy want to say goodbye to antiepileptic drugs immediately after epilepsy surgery, but in reality this is not possible, so why continue to take oral antiepileptic drugs after surgery? This is because of the possibility of residual epileptogenic foci after surgery; secondly, to prevent the development of new epileptogenic zones in the cortex with seizure potential; and thirdly, to prevent the formation of epileptogenic zones from surgical scars. What are the special requirements for post-surgical drug selection? The principle of using antiepileptic drugs after surgery is basically adjusted with reference to the preoperative medication, and it is better to discontinue the drugs with greater side effects and poorer results. If the prognosis after surgery is good, the number of preoperative medications should be reduced. In patients with only aura seizures, medication reduction can be considered based on seizure frequency, seizure performance and EEG. Patients with good efficacy in seizure control after surgery should also be medicated for 1-2 years and then decide whether the medication can be discontinued based on the EEG. If the results are not good after surgery, medication should be continued for a long time.