People at high genetic risk for breast cancer are divided into two main groups: the patients themselves and their relatives
I. Patients who meet one or more of the following characteristics.
1. young and mild breast cancer (≤ 50 years old)
2. Triple negative breast cancer (ER-, PR-, HER2-).
3. Patients with breast cancer of any age of onset who meet any of the following.
(1) Have a blood relative ≤ 50 years of age with breast cancer
(2) Have a blood relative with ovarian cancer
(3) Have ≥ 2 blood relatives (of any age) with breast or pancreatic cancer
(4) From a high-risk group (Nordic Jewish ethnic descendants)
(4) Having breast cancer concurrent with the following tumors.
Thyroid cancer.
Sarcoma.
adrenal cortical cancer.
Endometrial cancer.
Pancreatic cancer, brain tumors.
Diffuse gastric cancer (associated with CDH1).
Skin disease/macrocephaly (associated with PTEN).
Leukemia/lymphoma in the same family line (paternal or maternal side, especially with early onset).
5. ovarian cancer (including fallopian tube cancer and primary peritoneal cancer)
6.Male breast cancer.
II. Relatives of patients whose family history satisfies any of the following.
1, ≥ 2 primary breast cancers, either 1 patient (bilateral or multifocal) or 2 patients in the same family (maternal or paternal)
2. ≥ 1 patient with ovarian cancer in a consanguineous family
3. there is a patient with breast cancer ≤ 45 years old in the first or second degree relative
4. a family member with breast cancer who has one or more of the following tumors in the same family: thyroid cancer, sarcoma, adrenal cortical tumor, endometrial cancer, pancreatic cancer, brain tumor, diffuse hypofractionated carcinoma of the stomach, skin positive disease, macrosomia or leukemia/lymphoma (especially those with early onset)
5.Families with known genetic mutations in breast cancer.
6.Male breast cancer patients in the family.