The fine yellow verrucous rash is acute Niemann-Pick disease, a rare and fatal neurodegenerative disorder for which there is no effective treatment or prevention. Niemann-Pick disease occurs mainly in children before or during puberty and affects 1 in 150,000 children. The disease causes cholesterol and other lipids to build up in cells, eventually leading to motor neurodevelopmental delays, deterioration of memory and balance, and convulsions. So what can be done to prevent this disease? 1, antioxidant vitamin C, E or butylhydroxystilbene, can prevent the peroxidation and polymerization of unsaturated fatty acids contained in nerve sheath phospholipids M and reduce lipofuscin and free radical formation. 2.Splenectomy is suitable for those who are non-neurogenic and have hypersplenism.