Folic acid is not directly related to the NT test, as it is recommended to be taken in the first trimester of pregnancy until about 12 weeks of pregnancy, when the dosage can be increased or decreased according to the test results and doctor’s recommendations. The higher the NT number, the higher the chance of the fetus having Down’s syndrome. A good physical condition of both spouses can reduce the incidence of children with Down’s syndrome. Pregnant women should have timely medical checkups after pregnancy and keep an eye on the growth and development of the fetus. After the third trimester of pregnancy, the physical development of the fetus is basically formed, and taking folic acid tablets is less significant in preventing fetal developmental malformations. However, proper supplementation of folic acid can help prevent many pregnancy complications such as anemia, hypertension and diabetes during pregnancy. In addition, the dosage of folic acid needs to be adjusted under the guidance of a doctor to avoid the impact on the mother and the fetus.