Hormones are generally contraindicated in patients with tuberculosis because they are immunosuppressive and can suppress the cellular and humoral immune functions of the body, especially cellular immunity. The function of macrophages, lymphocytes and monocytes is reduced in patients with hormone use, thus its role in inhibiting the spread of Mycobacterium tuberculosis and killing Mycobacterium tuberculosis is significantly reduced, which easily leads to the spread of Mycobacterium tuberculosis and is not conducive to the control of the disease, and in serious cases, blood-borne disseminated tuberculosis can be formed, making the disease difficult to control. The use of hormones leads to an increase in the body’s blood sugar level, and a high blood sugar environment is more conducive to the multiplication of tuberculosis bacteria, and hormones are generally prohibited. However, there are exceptions to this rule. For some patients with severe symptoms of tuberculosis toxicity, such as some patients with tuberculous multiplasmatic effusion, especially pericardial effusion, and patients with hematogenous pulmonary tuberculosis, who may have significant hyperthermia, small doses of short course hormone therapy can be used appropriately, but only if they are treated with effective tuberculosis drugs.