Patients with pulmonary tuberculosis who have chest pain while taking anti-tuberculosis drugs mainly consider that the tuberculosis lesions involve the pleura and are pleuritic chest pain, which can be aggravated with breathing movement and coughing and has little relationship with taking anti-tuberculosis drugs. The occurrence of tuberculosis is due to the infection of lung tissue with Mycobacterium tuberculosis. When taking anti-tuberculosis drugs, it is impossible to kill all the Mycobacterium tuberculosis in the lung in a short time, and it is also impossible to recover all the lesions in the lung in a short time. If other bacterial infections are combined, chest pain may also occur when the pleura is involved. Of course, chest pain during anti-tuberculosis treatment needs to be improved with chest CT, ECG and other examinations to exclude the possibility of ineffectiveness of current anti-tuberculosis drugs or other diseases such as myocardial ischemia and pulmonary embolism.