Meningioma is a common intracranial tumor. Most meningiomas are solitary, but some meningiomas are multiple, meaning that there is more than one meningioma in the skull. However, multiple meningiomas are relatively rare, accounting for less than 10% of all meningiomas. Multiple meningiomas are common in women, with an approximate male to female incidence ratio of (1:3.5). The etiology of most meningiomas is not well understood and is sporadic. A small number of multiple meningiomas are associated with genetic mutations, some with germline mutations in the NF2 gene, possibly other tumors besides meningioma, a form of neurofibromatosis, and some multiple meningiomas are a manifestation of other familial tumor syndromes with germline mutations specific to familial tumor syndromes that predispose to various tumors, including meningioma. However, the proportion of such multiple meningiomas is also relatively small, accounting for only 1-9% of multiple meningiomas. Other meningiomas are related to the external environment, and one of the more certain factors is radiation. Treatment of multiple meningiomas is tricky, and Ms. Zhang is one such unfortunate patient with multiple meningiomas. She discovered two relatively small meningiomas in her head in 2013, and because the tumors were not very large and the symptoms were not too obvious, Ms. Zhang chose to closely monitor their growth with annual total brain MR exams. The first two or three years were relatively stable, but four years later in 2017, Ms. Zhang’s brain MRI was rechecked and found that the original tumors had grown significantly and were more numerous, at which time Ms. Zhang also developed symptoms of inflexibility in her arms and legs. Although the size, shape and even texture of the five tumors were different, the pathological diagnosis was that they were all mixed meningiomas, and after several months of recovery after the surgery, Ms. Zhang’s limb movement and other symptoms were significantly improved. However, after all, it was a multiple meningioma, and even though so many tumors had been removed, there were still several in the brain that had not been removed. By the end of 2020, Ms. Zhang again developed physical activity disorders and language problems, and MRI of the brain revealed that two of the remaining tumors had grown significantly larger than in previous years, creating a compressive effect. Ms. Zhang underwent surgery again, this time through two incisions to remove the two largest tumors, one in front and one in the back. After this surgery, although Ms. Zhang still had tumors in her brain, there was no significant compression of brain tissue and her symptoms were significantly better. Treatment for multiple meningiomas includes surgical resection, whole brain radiotherapy and stereotactic radiosurgery. However, for a specific case of multiple meningioma, an appropriate treatment plan needs to be developed based on the tumor and the actual condition of the patient. In general, surgery is used to remove large, fast-growing meningiomas with significant edema, while radiation therapy can be used to control the growth of a small number of meningiomas.