Many patients in the clinic will ask this question: “Why do I have kidney disease? I used to be in good health, and I can get over any problems after a while.” Indeed, until now technology is so advanced, we can do nothing about certain diseases, especially these autoimmune diseases, they are like masters in martial arts novels, appearing silently, creating a lot of big problems and making you suffer. These are because the source of the disease we have not yet found, but through increasingly advanced scientific research, we have been able to smell the traces of the disease occurring, such as chronic glomerulonephritis. The human immune system has three barriers, the first line of defense is the skin mucosa, the second line of defense is the non-specific immune system, consisting of bactericidal substances in body fluids and phagocytes, which directly kill pathogenic microorganisms that cross the skin mucosa and enter the body fluids, and the third line of defense is the specific immune system, which can act against a specific kind of pathogenic microorganisms and also retains the memory function to prevent secondary infections, if If the human immune system is compared to an army, the first line of defense is the border guard, the second line of defense is the mobile force of the major fortresses, and the third line of defense is the special forces, each of which has its own role in defending our health. When these forces, which are supposed to be united, have internal chaos and mutiny, the target of their attacks will turn to the normal tissues and organs of our body, thus creating diseases. Initially, many scholars believed that these three lines of defense existed relatively independently, and autoimmune diseases were mainly due to problems in the third line of defense, with an increase in self-reactive T and B cells, autoantibodies attacking normal tissues, and finally tissue damage, however, more and more studies now show that non-specific immunity and skin mucosa play an important role in immune abnormalities, and they are often the However, more and more research is now showing that non-specific immunity and skin mucosa play an important role in immune abnormalities, and they are often one of the causes of disease. A recent article by William G. Couser, an American physician, in 2015, states that the cause of chronic nephritis stems from the activation of the nonspecific immune system in certain genetic backgrounds, the disruption of the specific immune system, and eventually the appearance of autoantibodies. The reason why many hormones and immunosuppressants can always improve the condition in the treatment of the disease nowadays, but there is always a recurrence of nephritis or the inability to completely cure it, lies in the series of factors within the dotted line that we cannot correct simply through drugs, the disease cannot block the causative factors from the root, then it will always have a day of resurgence. Environmental exposure (smoking or passive smoking, polluted air, etc.), lifestyle (staying up late, obesity, high-fat diet, high-salt diet, etc.), frequent infections (skin, gastrointestinal tract, mouth, throat, etc.), various chronic inflammatory conditions (chronic hepatitis B), all of these will generate various reactions to our immune defenses such as skin mucosa and activate the non-specific immune system, and once our immune system is in abnormalities ( When the immune environment is altered) autoantibodies appear, they can directly attack the kidney tissues and also remain in the kidneys during excretion causing an inflammatory response that cannot be resolved by antibiotics because its source is not necessarily the infection. Therefore why the environment, infection, and lifestyle need to be emphasized in chronic nephritis is because they sway the source of disease occurrence. The genes you are born with do not judge your disease at birth, the greatest danger actually comes from the interaction between the body and the outside world, whether it is just right or overly random, these are the decisions you can make, and this is why doctors emphasize the importance of chronic disease management.